We have a database with tens of thousands of studies on the products we sell. Here we have summarised some of the most interesting studies related to Tongkat Ali and Cistanche.
Study 1
Study type:
Clinical trial (double-blind, placebo-controlled)
Dose:
600 mg/day of Tongkat Ali with 1.45% eurycomanone
Participants:
32 men aged from 20 to 30
Duration:
2 weeks
Results:
The researchers observed steroidogenic effects after Tongkat Ali supplementation. No adverse side effects were observed.
600mg/day was correlated with significant increases in testosterone (15%), free testosterone (34%) and estrogen (30%) levels. The testosterone level was raised slightly above the normal human range. The authors concluded that 600mg/day of Tongkat Ali could have a positive impact on sports performance.
Testosterone levels increased after 3 weeks of Tongkat Ali supplementation. The high dose of 600mg/d did not adversely affect liver function, renal function, blood profiles, electrolytes, cancer markers and the immune system.
Tongkat Ali supplementation was associated with significant increases in free testosterone. Males experienced a 682% average increase in free testosterone. Females experienced a 700% average increase in free testosterone.
106 males aged from 50 to 70 with low testosterone
Duration:
12 weeks
Results:
Tongkat ali supplementation was associated with significant increases in total testosterone. A dose of 200mg per day was associated with a 12.2% increase in total testosterone and a 16.9% increase in free testosterone.
Tongkat Ali was associated with significant improvements in erectile function, sexual libido and overall sexual satisfaction scores. Tongkat Ali was also associated with higher sperm motility and semen volume. The study also indicated that healthy, younger males may require doses higher than 300mg per day to increase testosterone levels.
26 men aged from 45 to 60 with mild erectile dysfunction
Duration:
12 weeks
Results:
Tongkat Ali supplementation was associated with significant improvements in the frequency of sexual performance, sexual satisfaction, penile erection and hardness, and overall sexual wellbeing. Participants also experienced an average increase in total testosterone by 36%. No adverse effects were observed; liver and kidney values showed no significant changes from baseline.
75 males (aged 33 on average) with idiopathic infertility
Duration:
3 months
Results:
Tongkat Ali supplementation was associated with significantly improved sperm quality (higher semen concentration, sperm motility and sperm concentration) and 11 spontaneous pregnancies.
Tongkat Ali supplementation was associated with significant improvements in reported stress levels, quality-of-life, mood, vigour, emotional well-being and cognition.
Tongkat Ali supplementation was associated with significant improvements in tension (-11%), confusion (-15%) and anger (-21%). Tongkat Ali was also associated with a reduction in cortisol (−16%) and increased testosterone (+37%). Note that cortisol levels generally increase in response to stress.
High-intensity resistance training; 2500mg of branched-chain amino acids; 1020mg of beta-alanine.
Participants:
32 young males with at least 1 year of experience in squatting, bench pressing and deadlifting.
Duration:
4 weeks
Results:
Tongkat Ali supplementation was associated with large strength increases in bench pressing (102kg to 108kg), squatting (120kg to 133kg) and deadlifting (158kg to 172kg), corresponding to an overall strength increase of 33kg. The placebo group experienced a much lower overall strength increase (24kg).
13 physically active males and 12 physically active females aged 57 to 72
Duration:
5 weeks
Results:
Tongkat Ali supplementation was associated with a strength increase of 16.6% in men and 13.7% in women after 5 weeks. These increases in muscle strength indirectly reflected an increase in muscle mass.
* Strength was measured with a hand dynamometer.
To determine the effects of Cistanche tubulosa extract on hormone levels and testicular steroidogenic enzymes in rats.
Results:
Cistanche tubulosa increased blood levels of testosterone and progesterone. It also increased sperm count 2.3 to 2.7-fold, increased sperm motility 1.3 to 1.4-fold, decreased abnormal sperm 0.76 to 0.6-fold, and increased the expression (activation) of the steroidogenic enzymes CYP11A1, CYP17A1, and CYP3A4. Steroidogenic enzymes are enzymes that are involved in steroid biosynthesis.
Conclusion:
Cistanche tubulosa extract decreased abnormal sperm and increased testosterone, progesterone, sperm count, sperm motility and the activation of enyzmes that are involved in the synthesis of steroid hormones.
To investigate the anti-inflammatory and protective effects of echinacoside in Cistanche tubulosa extracts on the reproductive system of male diabetic rats (echinacoside is an active component of Cistanche tubulosa).
Results:
Rats treated with various concentrations of echinacoside in Cistanche tubulosa extracts exhibited higher levels of testosterone than the non-treated diabetic rats. Similarly, the results of the cellular study indicated that eichinacoside restored the testosterone synthesis pathway.
Echinacoside also improved blood sugar levels, insulin resistance (the responsiveness of cells to insulin), leptin resistance (the body’s responsiveness to leptin, a hormone that signals the brain to stop eating when enough body fat has been stored), and lipid peroxidation (a process that causes oxidative deterioration of lipids, the fundamental building block of cells).
Summary:
Cistanche tubulosa and echinacosides increased testosterone and displayed anti-inflammatory and antioxidant benefits.
To investigate the proactive effects of Cistanche tubulosa and echinacoside (an active ingredient of Cistanche) against testicular and sperm toxicity.
Results:
Cistanche tubulosa and echinacoside normalised blood testosterone and reversed abnormalities in sperm characteristics and testicular structure. Cistanche and echinacoside also increased steroidogenic enzymes (enzymes involved in the production of steroid hormones), indicating that testosterone production was improved.
The results are especially interesting as the testicular toxicity was induced in the rats via a toxic chemical called bisphenol A (BPA) which has been used to make many plastics such as food containers since the 1950s. BPA is known to be an endocrine-disruptor, meaning that it interferes with the body’s hormones. Studies have indicated that BPA has estrogen-like activity and exhibits inhibitory effects on testosterone synthesis and developmental toxicity in the reproductive organs. Daily BPA exposure is unavoidable for most people.
This study indicated that Cistanche may help to protect against the potential effects of daily BPA exposure.
Conclusion:
Cistanche tubulosa and echinacoside improved testicular and sperm damage in rats.
To investigate the protective effects of echinacoside (echinacoside is an active component of Cistanche tubulosa) against infertility in rats.
Results:
Echinacoside increased sperm quantity and protected against oligoasthenospermia (low sperm count and sperm motility, a primary cause of male infertility). Echinacoside blocked androgen-receptor activity (the binding sites of testosterone) in the hypothalamus, thereby increasing testosterone.
Conclusion:
Echinacoside increased sperm quantity and protected against low sperm count and low sperm motility. It also increased levels of testosterone and luteinizing hormone.
Eichanoside from Cistanche tubulosa stimulated growth hormone secretion via activation of the ghrelin receptor. Note that the ghrelin receptor is the target of performance enhancing drugs and SARMS (drugs similar to anabolic steroids).
Conclusion:
Eichanoside from Cistanche tubulosa stimulated the secretion of growth hormone.
To examine the effects of Cistanche deserticola extract on penis erectile response.
Results:
The findings indicated that Cistanche deserticola shortened erectile latency and prolonged erectile duration to minimise the negative effects of castration.
The results also indicate that Cistanche deserticola regulated the blood concentration of luteinizing hormone to normal levels. In men, luteinizing hormone stimulates Leydig cells in the testes to produce testosterone. This acts to support sperm production.
Conclusion:
In castrated rats, the results indicated that Cistanche deserticola decreased the time taken to get an erection and increased the duration of erections.
To investigate the efficacy of Cistanche tubulosa and Laminaria japonica in preventing hair loss and promoting scalp health.
Number of participants:
94
Duration:
16 weeks
Results:
Researchers observed a statistically significant increase in the hair density of the test group after 16 weeks of Cistanche tubulosa and Laminaria japonica. Researchers also observed a statistically significant increase in hair diameter in the test group compared to control group at week 16. The test group also experienced greater improvements in dandruff compared to the control.
Conclusion:
Cistanche tubulosa extract was associated with improvements in patterned hair loss, dandruff and inflammation of the scalp.
To examine the antidepressant effects of Cistanche tubulosa.
Results:
The results showed promising effects as a potential therapy for depression.
The mice treated with Cistanche displayed:
1. An improved ability of spatial learning and memory.
2. Downregulated monoamine oxidase activity. It is important to note that monoamine oxidase inhibitors are used as antidepressant drugs. Monoamine oxidase is an enzyme that serves to inactivate monoamine neurotransmitters such as dopamine and serotonin.
3. Upregulated dopamine concentration in the brain (dopamine is a chemical involved in feelings of pleasure and motivation).
4. Downregulated blood concentration of corticosterone, indicating that the mice had reduced stress levels (corticosterone is a biomarker of stress levels).
To examine the impact of Cistanche tubulosa on markers of depression.
Results:
Cistanche tubulosa extract significantly improved depression-like behaviours in rats under chronic unpredictable stress. Cistanche restored levels of serotonin (serotonin plays a key role in mood stabilisation and sleep). Cistanche also restored BDNF protein expression (loss of BDNF is thought to be involved in depression).
To evaluate the effect of Cistanche in rats with Alzheimer’s disease-like pathology
Results:
More specifically, Cistanche reversed cholinergic and dopaminergic dysfunction in rats. The results are promising as Alzheimer’s disease is associated with cholinergic and dopaminergic dysfunction.
Conclusion:
Cistanche reversed dysfunction associated with Alzheimer’s disease.
Animal study (rodent model of Parkinson’s disease)
Purpose:
To identify potential therapeutic effects of Cistanche on Parkinson’s disease.
Results:
Cistanche had protective effects on dopaminergic neurons in a rodent model of Parkinson’s disease. This is promising as Parkinson’s disease mainly affects the dopamine-producing (“dopaminergic”) neurons.
Conclusion:
Cistanche treatment resulted in protective effects against Parkinson’s disease.
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How to use
Dosage
Take two 250mg Tongkat Ali capsules and two 200mg Cistanche capsules daily, ideally in the morning.
With or without food?
It's usually best to take Tongkat Ali with food in the morning. Some individuals feel nauseous when taking Tongkat Ali on an empty stomach due to rapid absorption or gastrointestinal irritation.
Cistanche can be taken with food or on an empty stomach. However, the impact of food on supplement absorption is often unpredictable as different compounds within food can interact with the supplement in different ways.
Erm well I don’t know whether it’s these or my new partner but we’re at it like rabbits and I’m 39 and thought my sex drive was falling. I hope it’s these tablets 🤣
C
Chris Jennings
Natural Libido Boost For Men - Cistanche & Tongkat Ali Proven To Boost Sex Drive
S
Stuart Powell
Natural Libido Boost For Men - Cistanche & Tongkat Ali Proven To Boost Sex Drive
V
Vin
Increase in strength, libido and 🍆 performance
Got the tongat ali, cistanche, turkersterone & also went with NMN to help with fatigue. These supplements really do work, ive ordered another month to keep it going.
P.s Word of warning libido will go through the roof, so make sure your wife/ partner is giving a heads up lol
P
Paul-Bogdan BARLADEANU
Natural Libido Boost For Men - Cistanche & Tongkat Ali Proven To Boost Sex Drive
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Cistanche is a type of plant that must grow on another plant in order to survive. It grows in dry conditions around the world. The stem of Cistanche is used for medicinal purposes.
Tongkat Ali is a herbal plant known as Eurycoma Longifolia that grows mainly in Peninsular Malaysia, Borneo, Indonesia, and in small patches in remote regions of Cambodia, Myanmar, and Laos. Tongkat Ali was used by Malaysians and indigenous peoples to treat diseases and as a natural aphrodisiac. Many believed Tongkat Ali is a symbol of virility, strength, power, and longevity for primal men.
Although most scientific studies have not observed any adverse side effects, one study observed mild gastrointestinal symptoms in 6 out of the 50 participants. These symptoms included constipation, indigestion, abdominal pain, flatulence and abdominal discomfort. To avoid gastrointestinal irritations, take the supplement with food and wait at least 24 hours before the next dose. Avoid taking the supplement on an empty stomach or after a heavy meal.
We are getting 99% of orders through without problem. If there is a problem, we can always return it to us and re-fund you. We have warehouses all over the world to make for a smooth shipping experience.
No. Tongkat Ali and Fadogia are not drugs. They are also not banned by WADA. However, we do not have a certification for our product so professional athletes may want to check with test authorities.
